Newly ID’d GLA mutations may be amenable to Galafold: Study

Researchers discovered new mutations in the GLA gene, the underlying cause of Fabry disease, but noted that all of them may be amenable to Galafold (migalastat) chaperone therapy, an approved treatment to slow or prevent organ function decline in Fabry patients, a new study reports. Clinical manifestations of…

Not all GLA gene mutations cause Fabry disease, case highlights

It’s critical to conduct thorough clinical evaluations to determine whether a newly identified mutation in the GLA gene is actually causing Fabry disease — before initiating treatment in patients. That’s the message highlighted in a report from Italy describing the case of a woman now in her early 40s whose GLA…

Fabry GLA gene mutations detected in Parkinson’s patients: Study

Researchers detected a mutation in the GLA gene, which is defective in Fabry disease patients, in people with Parkinson’s disease, a study revealed. Parkinson’s patients who carried this mutation showed signs of Fabry, particularly affecting the heart and nervous system. The findings follow a previous report that…

Rare Autoimmune Kidney Disorder Seen With Fabry Disease

The case of a man with Fabry disease that co-occurred with a rare autoimmune kidney disorder was described in a recent report. While it’s possible that the rare combination was coincidental, researchers speculated that damage to the kidneys resulting from Fabry disease might have set the stage for the…

Fabry Identified in Central Asian Family for First Time

Two cases of Fabry disease, diagnosed decades after symptom onset, were identified for the first time in a Central Asian family, a case study reported. Further analysis revealed many affected family members, demonstrating the importance of examining the relatives of people diagnosed with Fabry, the…